Description
Composition
Each tablet contains:
- Exemestane – 10 mg
- Excipients – q.s.
Pharmacological Effects
- Aromatase Inhibitor (AI): Steroidal, Irreversible (Type I).
- Primary Action: Binds permanently to the aromatase enzyme, blocking the conversion of androgens (testosterone, androstenedione) into estrogen (estradiol).
- Result: Lowers circulating estrogen levels by 50–85% (dose-dependent).
Indications
- Adjuvant treatment of Estrogen-Receptor-Positive (ER+) breast cancer in postmenopausal women.
- Prevention of breast cancer recurrence.
- Estrogen control in testosterone/anabolic steroid cycles (prevents gynecomastia, water retention).
- Post-Cycle Therapy (PCT) – sometimes used alongside SERMs (e.g., Clomid, Nolvadex).
Recommended Dose
- Breast Cancer: 25 mg once daily (oral, with food to improve absorption).
- Steroid Cycle Estrogen Control: 6.25–12.5 mg every other day (adjust based on bloodwork).
- Lower Doses: Often sufficient for TRT/light cycles.
- Higher Doses: Up to 25 mg/day may be needed in heavy aromatizing cycles (e.g., 500+ mg testosterone/week).
Side Effects
- Hot flashes (most frequent).
- Joint pain or stiffness (low estrogen reduces collagen synthesis).
- Fatigue or insomnia.
- Mild hair thinning (due to lowered estrogen).
Contraindication
- Premenopausal women (can cause ovarian hyperstimulation).
- Pregnancy/lactation (estrogen suppression harms fetal development).
- Severe liver/kidney disease.
- Allergy to Exemestane or other AIs (e.g., Anastrozole, Letrozole).
Storage Conditions
- Store at room temperature (15–30°C / 59–86°F).
- Protect from moisture and light (keep in original blister pack or bottle).
- Do not use if discoloured or crumbled.
Disclaimer: Always follow your healthcare provider’s advice regarding storage and use, especially when dealing with compounds that have limited clinical data.
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