Composition

Each tablet contains:

• Exemestane – 10 mg
• Excipients – q.s.

Pharmacological Effects

• Aromatase Inhibitor (AI): Steroidal, Irreversible (Type I).
• Primary Action: Binds permanently to the aromatase enzyme, blocking the conversion of androgens (testosterone, androstenedione) into estrogen (estradiol).
• Result: Lowers circulating estrogen levels by 50–85% (dose-dependent).

Indications

• Adjuvant treatment of Estrogen-Receptor-Positive (ER+) breast cancer in postmenopausal women.
• Prevention of breast cancer recurrence.
• Estrogen control in testosterone/anabolic steroid cycles (prevents gynecomastia, water retention).
• Post-Cycle Therapy (PCT) – sometimes used alongside SERMs (e.g., Clomid, Nolvadex).

Recommended Dose

• Breast Cancer: 25 mg once daily (oral, with food to improve absorption).
• Steroid Cycle Estrogen Control: 6.25–12.5 mg every other day (adjust based on bloodwork).
• Lower Doses: Often sufficient for TRT/light cycles.
• Higher Doses: Up to 25 mg/day may be needed in heavy aromatizing cycles (e.g., 500+ mg testosterone/week).

Side Effects

• Hot flashes (most frequent).
• Joint pain or stiffness (low estrogen reduces collagen synthesis).
• Fatigue or insomnia.
• Mild hair thinning (due to lowered estrogen).

Contraindication

• Premenopausal women (can cause ovarian hyperstimulation).
• Pregnancy/lactation (estrogen suppression harms fetal development).
• Severe liver/kidney disease.
• Allergy to Exemestane or other AIs (e.g., Anastrozole, Letrozole).

Storage Conditions

• Store at room temperature (15–30°C / 59–86°F).
• Protect from moisture and light (keep in original blister pack or bottle).
• Do not use if discoloured or crumbled.

Disclaimer: Always follow your healthcare provider’s advice regarding storage and use, especially when dealing with compounds that have limited clinical data.