Retatrutide 5/10 mg

Composition

Each pack contains:

• One vial with Retatrutide – 5 mg (GIP/GLP-1/Glucagon receptor agonist)
• One ampoule with 2 ml sterile water for injection

Pharmacological Effects

• GIP Receptor Agonism:
  • Enhances insulin secretion (glucose-dependent).
  • Promotes adipose tissue metabolism, aiding weight loss.
• GLP-1 Receptor Agonism:
  • Increases insulin secretion and suppresses glucagon.
  • Delays gastric emptying → reduces appetite.
• Glucagon Receptor Agonism:
  • Increases energy expenditure via hepatic metabolism.
  • May counteract GLP-1–induced metabolic slowdown.
• Net Clinical Effects:
  • Improved glycemic control (HbA1c reduction).
  • Significant weight loss (superior to GLP-1 agonists alone).
  • Potential cardiovascular benefits (under investigation).

Indications

• Type 2 diabetes mellitus (adjunct to diet and exercise).
• Chronic weight management (BMI ≥30, or ≥27 with comorbidities).
• Metabolic syndrome (investigational/ future use).

Recommended Dose

• Starting dose: 2–4 mg once weekly (subcutaneous).
• Maintenance dose: 5–12 mg weekly, titrated over 4–8 weeks.
• Administration: Subcutaneous injection into abdomen, thigh, or upper arm.

Side Effects

Common (≥10%)

• Nausea, vomiting, diarrhea, constipation.
• Decreased appetite.
• Injection-site reactions.

Less Common (1–10%)

• Hypoglycemia (more likely with insulin or sulfonylureas).
• Gallbladder issues (e.g., cholelithiasis).
• Fatigue, dizziness.

Contraindication

• Personal or family history of medullary thyroid carcinoma (MTC).
• Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
• Severe gastrointestinal disease (e.g., gastroparesis).
• Pregnancy or breastfeeding (insufficient safety data).
• Hypersensitivity to Retatrutide or any excipients.

Storage Conditions

• Unopened vials: Store refrigerated at 2–8°C (do not freeze).
• Protect from light and keep sealed until reconstitution.

Disclaimer: This product is not for human use. It is intended for laboratory research only. Not for diagnostic, therapeutic, or veterinary purposes. Buyer assumes all responsibility for proper handling and legal compliance. Keep out of reach of children.